By: David Baldwin, Kevin Bridgman, Christel Buis
The selective noradrenaline re-uptake inhibitor reboxetine may have advantages over the selective serotonin re-uptake inhibitors fluoxetine and citalopram, in effects on sexual function and satisfaction. The effects of reboxetine and paroxetine on sexual function were compared by examining data from the UK centres in an international double-blind flexible-dose parallel-group multi-centre randomized controlled trial of acute treatment of patients with DSM-IV major depression.
Patients were randomly assigned to receive reboxetine (4mg b.d.) or paroxetine (20mg mane) using a double-dummy technique to preserve the blind. The dosage could be increased at day 28 (to reboxetine 4mg mane, 6mg nocte; or paroxetine 20mg b.d.). Antidepressant efficacy was assessed by the 21-item Hamilton Rating Scale for Depression (HAM-D) and Clinical Global Impression Scale for Severity (CGI-S) at all study visits, and the Clinical Global Impression of Improvement (CGI-I) at each visit after randomization. Sexual function and satisfaction was assessed by visual analogue scale (VAS) items of the Rush Sexual Inventory completed at baseline and days 28 and 56.
There were no significant differences between groups in demographic or clinical features at baseline. There was a gradual reduction in severity of depressive symptoms (reboxetine, 14.3; paroxetine, 12.0: observed case analysis), with no significant differences between groups. There were significant differences (p 0.05), with advantages for reboxetine, at Week 4 and Week 8 on the VAS item assessing ability to become sexually excited, and non-significant trends with advantages for reboxetine, in frequency of sexual thoughts at Week 4 (p 0.05) and Week 8 (p 0.08); and in desire to initiate sexual activity at Week 4 (p 0.09). Exclusion of patients who had ever experienced sexual dysfunction with any medication prior to participation in this study (n 10) reduced the statistical significance of the findings, although there were still numerical advantages for reboxetine.
Sexual function and satisfaction in depressed patients improves during double-blind acute treatment with reboxetine or paroxetine, but this improvement is greater and more rapid with reboxetine.
IN THE WORKPLACE
New Research on Depression in the Workplace.
For more information please click here
To subscribe to SADAG's newsletter, click here
Mental Health Matters Journal for Psychiatrists & GP's
Click here for more info on articles & how to subscribe
Literacy is a luxury that many of us take for granted. We depend on written communication for information, guidance, and access to heath care information That is why SADAG created SPEAKING BOOKS and revolutionized the way information is delivered to low literacy communities. It's exactly what it sounds like.a book that talks to the reader in his or her local language, delivering critical information in an interactive, and educational way.
The customizable 16-page book, accompanied by local celebrity audio recordings, ensures that vital health and social messages can be seen, heard, read and understood..
We started with books on Teen Suicide prevention , HIV, AIDS and Depression, Understanding Mental Health and have developed over 30 titles, such as TB, Malaria, Polio, Vaccines for over 30 countries.
- Click here to see speaking books in action
- Click here for sample book on clinical trials
- Click here for latest press release 1.
- Click here for latest press release 2.
- Click here to connect to international site www.booksofhope.com
- Speaking books for Health Care YouTube
Depression and Sexual Dysfunction
By: David Baldwin, Kevin Bridgman, Christel Buis
Dr Reddy's Help Line
0800 21 22 23
Pharmadynamics Police &Trauma Line
0800 20 50 26
Adcock Ingram Depression and Anxiety Helpline
0800 70 80 90
Destiny Helpline for Youth & Students
0800 41 42 43
0800 55 44 33
Department of Social Development Substance Abuse Line 24hr helpline
0800 12 13 14
Suicide Crisis Line
0800 567 567
SADAG Mental Health Line
011 234 4837
Akeso Psychiatric Response Unit 24 Hour
0861 435 787
Cipla Mental Health Helpline
0800 456 789
MENTAL HEALTH CALENDAR 2018
Teen Suicide Prevention Week
11 - 18 February
Bipolar Awareness Day
Substance Abuse Awareness Day
Mental Health Awareness Month
1 – 31 July
Panic Awareness Day
World Suicide Prevention Day
World Mental Health Day
View our list of informative Infographs.
SADAG KZN Branch
SADAG have launched a new office in Durban with the support of Psychiatrist Dr Suvira Ramlall and Clinical Psychologist, Suntosh Pillay.
The offices are placed in St Joseph’s Hospital and are managed by Lyn Norton.
The KZN Branch is deeply committed to;
- Launching new Support Groups
- Workshops on aspects of Mental Health
- School Talks on Suicide Prevention
- Corporate Wellness For KZN companies
Please click here for more information about the KZN activities.
Want to become a volunteer counsellor? Contact Michelle/Christine 0800 21 22 23
Download Application Form Here
If you are interested in starting a Support Group, please contact Michelle on 0800 21 22 23.
To find a Support Group in your area, please phone SADAG on 0800 21 22 23.
If you are a journalist writing a story contact Cassey on
011 234 4837 /firstname.lastname@example.org